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O6-methylguanine-DNA methyltransferase activities in biopsies of human melanoma tumours

✍ Scribed by Egyházi, S; Hansson, J; Ringborg, U


Book ID
109837209
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
580 KB
Volume
71
Category
Article
ISSN
0007-0920

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Activity of 06-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkyIguanines in DNA by accepting the alkyl group at a cysteine moiety. Inactivation of MGMT is a feasible way to ove