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Exploiting the role of O6-methylguanine-DNA-methyltransferase (MGMT) in cancer therapy

✍ Scribed by Ami Sabharwal; Mark R Middleton


Book ID
116383460
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
282 KB
Volume
6
Category
Article
ISSN
1471-4892

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## Abstract Promotor hypermethylation is a common event in human cancer. __O^6^‐Methylguanine‐DNA Methyltransferase__ (__MGMT__) is a gene involved in DNA repair, which is methylated in a variety of cancer types. In colorectal cancer and lung cancer, hypermethylation of __MGMT__ has been correlated