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O6-methylguanine-DNA methyltransferase (MGMT): impact on cancer risk in response to tobacco smoke

✍ Scribed by Markus Christmann; Bernd Kaina


Book ID
116758693
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
597 KB
Volume
736
Category
Article
ISSN
0027-5107

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Activity of O6-methylguanine-DNA methylt
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The DNA-repair protein O 6 -methylguanine-DNA methyltransferase (alkyltransferase; MGMT) is a major determinant of resistance of cells to various alkylating cytostatic drugs. Its expression in tissues is highly variable, indicating complex regulatory mechanisms involved. Transfection-mediated expres