Differential inactivation of O6-methylgu
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Katsuyoshi Mineura; Masahito Fukuchi; Masayoshi Kowada; Isamu Terashima; Kohfuku
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Article
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1995
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John Wiley and Sons
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French
β 473 KB
Activity of 06-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkyIguanines in DNA by accepting the alkyl group at a cysteine moiety. Inactivation of MGMT is a feasible way to ove