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Evidence for a novel mechanism of androgen resistance in the human prostate cancer cell line, PC-3

✍ Scribed by Wayne D. Tilley; Jacqueline M. Bentel; James O. Aspinall; Rosemary E. Hall; David J. Horsfall


Book ID
116065846
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
976 KB
Volume
60
Category
Article
ISSN
0039-128X

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Androgen receptors and hormone sensitivi
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Androgen receptors are expressed at a low level in the cell line PC-3, which does not respond to either androgens or antiandrogens. If these cells are exposed to natural beta-interferon (beta-IFN) a reduction in cell growth and an increase in androgen receptors, evaluated by both biochemical and imm