DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: Implications for the androgen receptor functions and regulation
โ Scribed by Fatouma Alimirah; Jianming Chen; Zane Basrawala; Hong Xin; Divaker Choubey
- Book ID
- 116466542
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 268 KB
- Volume
- 580
- Category
- Article
- ISSN
- 0014-5793
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## Abstract We previously demonstrated that ectopic expression of neurotrophic peptide (NP) derived from saposin C promotes androgen receptor (AR) expression and transactivation in human prostate cancer cells. This prompted us to investigate how NP or saposin C can function in cells. We constructed
## Background: The presence and possible role of androgen-metabolizing enzymes in androgen-independent prostate carcinoma (cap) are still unclear. the aim of the present study was: 1) to evaluate the pattern of androgen metabolism (relative production of 5alpha-reduced vs. 17-keto androgens); and 2