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Mechanisms of resistance and adaptation to thapsigargin in androgen-independent prostate cancer PC3 and DU145 cells

โœ Scribed by Dong I. Lee; Carlota Sumbilla; Myounghee Lee; Chidambaram Natesavelalar; Michael G. Klein; Douglas D. Ross; Giuseppe Inesi; Arif Hussain


Book ID
116177900
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
552 KB
Volume
464
Category
Article
ISSN
0003-9861

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## Background: The presence and possible role of androgen-metabolizing enzymes in androgen-independent prostate carcinoma (cap) are still unclear. the aim of the present study was: 1) to evaluate the pattern of androgen metabolism (relative production of 5alpha-reduced vs. 17-keto androgens); and 2