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Evaluation of the use of cyclodextrins in chiral separation of basic drug substances by capillary electrophoresis

✍ Scribed by Dr. Inga Bjørnsdottir; Steen Honoré Hansen

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
442 KB
Volume
7
Category
Article
ISSN
0899-0042

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✦ Synopsis

The influence of the choice of type and/or concentration of cyclodextrin, other additives, the temperature surrounding the capillary, and buffer pH on the separation of some chiral basic drug substances in capillary zone electrophoresis has been evaluated. It was found that pH of the buffer and type and concentration of cyclodextrin had a major influence on the separation.

📜 SIMILAR VOLUMES

Separation of basic drugs by capillary e
Separation of basic drugs by capillary electrophoresis using selectively modified cyclodextrins as chiral selectors
✍ Gerald Weseloh; Holger Bartsch; Wilfried A. König 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 474 KB

## Abstract The influence of seven differently methylated β‐cyclodextrin derivatives and of pure β‐cyclodextrin (β‐CD) on the enantiomeric resolution by capillary electrophoresis of six basic chiral pharmaceuticals is investigated. The methyl substitution pattern affects enantioselectivity much mor

Chiral selective separation of tocainide
Chiral selective separation of tocainide by capillary electrophoresis using various cyclodextrin derivatives
✍ Zoltán Juvancz; Karin E. Markides; László Jicsinszky; Róbert Iványi 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 102 KB

## Abstract Chiral separation of tocainide, an antiarrythmic agent, was solved using the capillary electrophoresis method. Fifteen types of cyclodextrins were tried as chiral selective buffer additives, and baseline separation was achieved with five of them. The variables that were studied comprise