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Separation of basic drugs by capillary electrophoresis using selectively modified cyclodextrins as chiral selectors

✍ Scribed by Gerald Weseloh; Holger Bartsch; Wilfried A. König

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 474 KB
Volume: 7
Category: Article
ISSN: 1040-7685
DOI: 10.1002/mcs.1220070408

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✦ Synopsis

Abstract

The influence of seven differently methylated β‐cyclodextrin derivatives and of pure β‐cyclodextrin (β‐CD) on the enantiomeric resolution by capillary electrophoresis of six basic chiral pharmaceuticals is investigated. The methyl substitution pattern affects enantioselectivity much more than other experimental parameters. The purity of the used cyclodextrin derivatives is analyzed by successive hydrolysis, reduction, acetylation, and GC/MS of each CD derivative and by MALDI‐TOF mass spectrometry. © 1995 John Wiley & Sons, Inc.

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