Separation of basic drug enantiomers by capillary zone electrophoresis using glucuronyl glucosyl β-cyclodextrin as a chiral selector
✍ Scribed by Hisami Matsunaga; Jun Haginaka
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 122 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0173-0835
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📜 SIMILAR VOLUMES
A negatively charged cyclodextrin, sulfated -cyclodextrin -CD-Ž y . x SO , was used as a chiral selector for capillary electrophoresis separations of 4 4 basic pharmaceutical enantiomers. The charges of the basic enantiomers were controlled by adjusting the buffer pH. At pH 2.5, basic compounds a
## Capillary electrophoresis has developed into an extremely useful technique for the separation of optical isomers. High efficiencies and the availability of many types of isomer selectors allowing rapid and inexpensive methods development make capillary electrophoresis (CE) an attractive alternat
Following an extended chiral drug screening program by capillary zone electrophoresis (CZE), the enantioseparation of 86 racemic drugs was tested with ␥cyclodextrin as a chiral solvating agent. Unified conditions were applied to all experiments. In total, 18 drug racemates were separated, 13 entries