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Enantiomeric separation of acidic drugs by capillary electrophoresis using a combination of charged and uncharged β-cyclodextrins as chiral selectors

✍ Scribed by Fillet, Marianne ;Bechet, Isabelle ;Schomburg, Gerhard ;Hubert, Philippe ;Crommen, Jacques

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
472 KB
Volume
19
Category
Article
ISSN
0935-6304

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✦ Synopsis

Abstract

High resolution could be achieved for the enantiomers of acidic drugs, namely, sulindac, fenoprofen, ketoprofen, warfarin, and hexobarbital, in a buffer of pH 3 by the simultaneous addition of uncharged and charged β‐cyclodextrin derivatives. The interaction of the analytes with the anionic sulfobutyl ether β‐cyclodextrin provides the analytes with an adequate electrophoretic mobility whereas the interaction with various neutral β‐cyclodextrins generates high enantioselectivity. Five neutral cyclodextrins, the native β‐cyclodextrin, as well as methyl‐, dimethyl‐, trimethyl‐ and hydroxypropyl‐β‐cyclodextrin, were tested to enhance the enantioselectivity of the electrophoretic system. High resolution values and the shortest analysis times for the five drugs tested were achieved in a buffer made of 100 mM phosphoric acid adjusted to pH 3 with triethanolamine and containing dimethyl‐ or trimethyl‐β‐cyclodextrin in addition to sulfobutyl ether β‐cyclodextrin.

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