## Abstract The influence of seven differently methylated Ξ²βcyclodextrin derivatives and of pure Ξ²βcyclodextrin (Ξ²βCD) on the enantiomeric resolution by capillary electrophoresis of six basic chiral pharmaceuticals is investigated. The methyl substitution pattern affects enantioselectivity much mor
Capillary electrophoresis chiral separations of basic compounds using cationic cyclodextrin
β Scribed by Fang Wang; Professor Morteza G. Khaledi
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 485 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0173-0835
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A negatively charged cyclodextrin, sulfated β€-cyclodextrin β€-CD-Ε½ y . x SO , was used as a chiral selector for capillary electrophoresis separations of 4 4 basic pharmaceutical enantiomers. The charges of the basic enantiomers were controlled by adjusting the buffer pH. At pH 2.5, basic compounds a
Chiral separation methods development using conventional t e c h q u e s such as GC or HPLC requires a lot of experience, effort, and expense, due to the wide diversity of the optically active solutes and their possible chiral selectors. Capillary electrophoresis has received increased attention as
The influence of the choice of type and/or concentration of cyclodextrin, other additives, the temperature surrounding the capillary, and buffer pH on the separation of some chiral basic drug substances in capillary zone electrophoresis has been evaluated. It was found that pH of the buffer and type