Preparation of a demonstration library of a,a-disubstituted-a-acylaminoketones, of interest as ecdysone agonists, is described. The five-step synthetic sequence employed a,a-disubstituted amino acids, Grignard reagents and carboxylic acids as building blocks in a strategic combination of solid phase
✦ LIBER ✦
Evaluation of Solution and Solid-Phase Approaches to the Synthesis of Libraries of α,α-Disubstituted-α-acylaminoketones
✍ Scribed by Garcia, Javier; Mata, Ernesto G.; Tice, Colin M.; Hormann, Robert E.; Nicolas, Ernesto; Albericio, Fernando; Michelotti, Enrique L.
- Book ID
- 121491534
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 486 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1520-4766
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