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Evaluation of Solution and Solid-Phase Approaches to the Synthesis of Libraries of α,α-Disubstituted-α-acylaminoketones

✍ Scribed by Garcia, Javier; Mata, Ernesto G.; Tice, Colin M.; Hormann, Robert E.; Nicolas, Ernesto; Albericio, Fernando; Michelotti, Enrique L.


Book ID
121491534
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
486 KB
Volume
7
Category
Article
ISSN
1520-4766

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Combined solid phase and solution synthe
✍ Javier Garcia; Ernesto Nicolàs; Fernando Albericio; Enrique L. Michelotti; Colin 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 134 KB

Preparation of a demonstration library of a,a-disubstituted-a-acylaminoketones, of interest as ecdysone agonists, is described. The five-step synthetic sequence employed a,a-disubstituted amino acids, Grignard reagents and carboxylic acids as building blocks in a strategic combination of solid phase

Solid phase synthesis of α-acylamino-α,α
✍ Colin M. Tice; Enrique L. Michelotti; Ernesto G. Mata; Ernesto Nicolàs; Javier G 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 150 KB

a-Acylamino-a,a-disubstituted ketones are of interest as ecdysone agonists. Solid phase synthesis of prototypical a-acylamino-a,a-disubstituted ketones on two different solid supports is described. In both cases the ketone was formed by reaction of a Grignard reagent with an N-acyl-a,a-disubstituted