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DAST-Mediated Cyclization of α,α-Disubstituted-α-acylaminoketones: Efficient and Divergent Synthesis of Unprecedented Heterocycles

✍ Scribed by Bigot, Aurélien; Blythe, Judith; Pandya, Chirag; Wagner, Trixie; Loiseleur, Olivier


Book ID
126987593
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
269 KB
Volume
13
Category
Article
ISSN
1523-7060

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✍ Javier Garcia; Ernesto Nicolàs; Fernando Albericio; Enrique L. Michelotti; Colin 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 134 KB

Preparation of a demonstration library of a,a-disubstituted-a-acylaminoketones, of interest as ecdysone agonists, is described. The five-step synthetic sequence employed a,a-disubstituted amino acids, Grignard reagents and carboxylic acids as building blocks in a strategic combination of solid phase