𝔖 Bobbio Scriptorium
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Errors of heterologous protein expression

✍ Scribed by Charles Kurland; Jonathan Gallant

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
419 KB
Volume
7
Category
Article
ISSN
0958-1669

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✦ Synopsis

Missense substitutions and processivity errors in the translation of heterologous proteins are expected to occur at higher frequencies than the corresponding errors of normal translation. The resulting error-containing products may overload chaperone systems. Likewise, there may be a risk of an immunogenic response to heterologous proteins introduced into vertebrates. Recent work has been carried out on the mechanisms by which such errors arise and on their occurrence in cloned, heterologous gene products.

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