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Enzymatic synthesis of carbon-11 acetyl coenzyme A

✍ Scribed by Geert Mannens; Guido Slegers; Raf Lambrecht; Patrick Goethals

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
314 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

An enzymatic synthesis of ["Cl acetyl coenzyme

A from [l-l'c] acetate is described. "COZ was reacted with methylmagnesium bromide in diethyl ether at 0 'C. The excess of Grignard reagent was hydrolyzed by adding methanol. After evaporation of the solvents, the residue was redissolved in hydrochloric acid and [l-llC]acetic acid was removed by acid distillation. In the presence of cofactors the [l-"C]acetic acid was sent over an enzyme reactor containing immobilized acetyl coenzyme A synthetase (Acetate : CoA ligase

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