Mechanisms of resistance to acetyl-coenzyme A carboxylase inhibitors: a review

✍ Scribed by Devine, Malcolm D.

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 221 KB
• Volume: 51
• Category: Article
• ISSN: 1526-498X
• DOI: 10.1002/(sici)1096-9063(199711)51:3<259::aid-ps644>3.0.co;2-s

✦ Synopsis

Resistance to acetyl-coenzyme A carboxylase (ACCase) inhibitors has developed in at least 10 grass weed species in recent years. In most instances, resistance is conferred by an ACCase alteration in the resistant biotypes that reduces sensitivity to aryloxyphenoxypropionate (AOPP) and cyclohexanedione (CHD) herbicides. Analysis of ACCase from many of these resistant weed biotypes suggests the presence of di †erent mutations, each conferring a di †erent pattern and level of resistance to various AOPP and CHD herbicides. In all cases analyzed to date, resistance is controlled by a single dominant or semidominant nuclear gene. In several weed biotypes, resistance is conferred by enhanced herbicide detoxiÐcation, primarily through elevated expression or activity of cytochrome P450 monooxygenase(s). This mechanism can confer cross-resistance to herbicides from other chemical classes with di †erent modes of action. Finally, multiple herbicide resistance, i.e. the acquisition of several di †erent resistance mechanisms, has been reported in some weed biotypes.