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Enzymatic synthesis of 11C-labelled (−)-epinephrine

✍ Scribed by Robert Soussain; Paul Gueguen; Jean-Louis Morgat; Mariannick Maziere; Gérard Berger; Dominique Comar

Publisher
John Wiley and Sons
Year
1984
Tongue
French
Weight
731 KB
Volume
21
Category
Article
ISSN
0022-2135

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✦ Synopsis

An enzymatic method is described for the synthesis of llC-labelled (-)-epinephrine in which the c1 'Clrnethyl group is sequencially transferred from L-[methyl-l lC]methionine to ( -) -norepinephrine via S-adenosyl-L-[methyl-l ' C ] r n ethionine respectively by the enzymes L-methionine-S-adenosine transferase (M.A.T) and phenylethanolamine-N-methyl transferase (P.N.M.T). Chromatographically pure "C-epinephrine having a specific activity approximately 200 Ci/mmol is obtained 35 minutes after the synthesis of the starting compound L-[methyl-llC]methionine.

Preliminary results are presented for the dynamics of the distribution of the "C-epinephrine in organs of the rabbit by gamma scintigraphy.

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