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Enantioselective Total Synthesis of the Antihypertensive Agent (S,R,R,R)-Nebivolol

✍ Scribed by S Chandrasekhar; M Venkat Reddy

Book ID: 104202877
Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 136 KB
Volume: 56
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(00)00572-x

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✦ Synopsis

AbstractÐThe total synthesis of (S,R,R,R)-Nebivolol, a hypertensive agent, is reported. Claisen rearrangement and a one-pot Sharpless asymmetric epoxidation, intramolecular epoxide opening with internal phenoxide anion to generate the chiral chromane are the key steps.

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