ChemInform Abstract: Enantioselective Total Synthesis of the (-)-(6R,11R,14S)-Isomer of Colletallol.

✍ Scribed by S. J. AMIGONI; L. J. TOUPET; Y. J. LE FLOC'H

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 34 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199801255

✦ Synopsis

Enantioselective Total Synthesis of the (-)-(6R,11R,14S)-Isomer of Colletallol. -The total synthesis of title compound (VII) is based on two consecutive Wittig reactions, the first one intermolecular and the second one intramolecular, instead of classical macrolactonizations. The strategy is flexible and should be useful for the preparation of further macrolide antibiotics. -(AMIGONI, S.