AbstractÐThe total synthesis of (S,R,R,R)-Nebivolol, a hypertensive agent, is reported. Claisen rearrangement and a one-pot Sharpless asymmetric epoxidation, intramolecular epoxide opening with internal phenoxide anion to generate the chiral chromane are the key steps.
✦ LIBER ✦
Sulfoxide-Directed Stereocontrolled Access to 2H-Chromans: Total Synthesis of the (S,R,R,R)-Enantiomer of the Antihypertensive Drug Nebivolol
✍ Scribed by M. Carmen Carreño; Gloria Hernández-Torres; Antonio Urbano; Françoise Colobert
- Book ID
- 102173025
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 148 KB
- Volume
- 2008
- Category
- Article
- ISSN
- 1434-193X
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