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Enantioselective Desymmetrization of meso Epoxides with Anilines Catalyzed by a Niobium Complex of a Chiral Multidentate Binol Derivative.

✍ Scribed by Kenzo Arai; Matthew M. Salter; Yasuhiro Yamashita; Shu Kobayashi


Publisher
John Wiley and Sons
Year
2007
Weight
36 KB
Volume
38
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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## Abstract Catalyzed by the Mg complexes of BINOL derivatives, the enantioselective ring opening reaction of various __meso__‐epoxides proceeded smoothly with either aromatic or aliphatic amines as the nucleophiles to afford the corresponding chiral β‐amino alcohols in moderate‐to‐high yields with

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## Abstract The reaction with anilines is catalyzed by the (R)‐BINOL/Bu~2~Mg/MeLi system and tolerates a wide range of functional groups [cf.