Enantioselective Desymmetrization of meso Epoxides with Anilines Catalyzed by a Niobium Complex of a Chiral Multidentate Binol Derivative.
β Scribed by Kenzo Arai; Matthew M. Salter; Yasuhiro Yamashita; Shu Kobayashi
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 36 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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π SIMILAR VOLUMES
## Abstract Catalyzed by the Mg complexes of BINOL derivatives, the enantioselective ring opening reaction of various __meso__βepoxides proceeded smoothly with either aromatic or aliphatic amines as the nucleophiles to afford the corresponding chiral Ξ²βamino alcohols in moderateβtoβhigh yields with
## Abstract The reaction with anilines is catalyzed by the (R)βBINOL/Bu~2~Mg/MeLi system and tolerates a wide range of functional groups [cf.