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Enantioselective Desymmetrization of meso Epoxides with Anilines Catalyzed by a Niobium Complex of a Chiral Multidentate Binol Derivative
✍ Scribed by Kenzo Arai; Matthew M. Salter; Yasuhiro Yamashita; Shū Kobayashi
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 94 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0044-8249
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## Abstract Catalyzed by the Mg complexes of BINOL derivatives, the enantioselective ring opening reaction of various __meso__‐epoxides proceeded smoothly with either aromatic or aliphatic amines as the nucleophiles to afford the corresponding chiral β‐amino alcohols in moderate‐to‐high yields with
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## Abstract The reaction with anilines is catalyzed by the (R)‐BINOL/Bu~2~Mg/MeLi system and tolerates a wide range of functional groups [cf.