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Enantioselective Addition of Diethylzinc to Aromatic Aldehydes Catalyzed by Pyrolidine and Piperidine β-Amino Alcohols

✍ Scribed by Salehi, Peyman; Dabiri, Minoo; Kozehgary, Gholamreza; Heydari, Seddigheh


Book ID
120836891
Publisher
Taylor and Francis Group
Year
2009
Tongue
English
Weight
210 KB
Volume
39
Category
Article
ISSN
0039-7911

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Enantioselective addition of diethylzinc
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## Abstract β‐Amino alcohols derived from (1__R__,2__S__)‐norephedrine were synthesized and used as ligands in the catalytic enantioselective diethylzinc addition to benzaldehydes. __N__‐alkylated (1__R__,2__S__)‐norephedrine‐based derivative 3a gave the highest enantioselectivity. The effects of d

Enantioselective addition of diethylzinc
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A (+)-3-carene derived aminoalcohol was successfully used as a chiral ligand in the catalytic enantioselective diethylzinc addition to various aldehydes. Very high enantiomeric excess (up 98% in 1-(2-methoxyphenyl)-1-propanol) was obtained. A plausible mechanism has been suggested for the observed e