Enantioselective Addition of Diethylzinc to Aromatic Aldehydes Catalyzed by Pyrolidine and Piperidine β-Amino Alcohols
✍ Scribed by Salehi, Peyman; Dabiri, Minoo; Kozehgary, Gholamreza; Heydari, Seddigheh
- Book ID
- 120836891
- Publisher
- Taylor and Francis Group
- Year
- 2009
- Tongue
- English
- Weight
- 210 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0039-7911
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📜 SIMILAR VOLUMES
## Abstract β‐Amino alcohols derived from (1__R__,2__S__)‐norephedrine were synthesized and used as ligands in the catalytic enantioselective diethylzinc addition to benzaldehydes. __N__‐alkylated (1__R__,2__S__)‐norephedrine‐based derivative 3a gave the highest enantioselectivity. The effects of d
A (+)-3-carene derived aminoalcohol was successfully used as a chiral ligand in the catalytic enantioselective diethylzinc addition to various aldehydes. Very high enantiomeric excess (up 98% in 1-(2-methoxyphenyl)-1-propanol) was obtained. A plausible mechanism has been suggested for the observed e