Enantioselective Addition of Diethylzinc to Aldehydes Catalyzed by N -(9-Phenylfluoren-9-yl) β-Amino Alcohols
✍ Scribed by Paleo, M. Rita; Cabeza, Isabel; Sardina, F. Javier
- Book ID
- 121301463
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 89 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
## Abstract β‐Amino alcohols derived from (1__R__,2__S__)‐norephedrine were synthesized and used as ligands in the catalytic enantioselective diethylzinc addition to benzaldehydes. __N__‐alkylated (1__R__,2__S__)‐norephedrine‐based derivative 3a gave the highest enantioselectivity. The effects of d
A (+)-3-carene derived aminoalcohol was successfully used as a chiral ligand in the catalytic enantioselective diethylzinc addition to various aldehydes. Very high enantiomeric excess (up 98% in 1-(2-methoxyphenyl)-1-propanol) was obtained. A plausible mechanism has been suggested for the observed e