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Enantioselective addition of diethylzinc to aldehydes catalyzed by optically active C2-symmetrical bis-β-amino alcohols

✍ Scribed by Qianyong Xu; Guangming Zhu; Xinfu Pan; Albert S.C. Chan


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
122 KB
Volume
14
Category
Article
ISSN
0899-0042

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Enantioselective addition of diethylzinc
✍ Dilek Isik Tasgin; Canan Unaleroglu 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 123 KB 👁 1 views

## Abstract β‐Amino alcohols derived from (1__R__,2__S__)‐norephedrine were synthesized and used as ligands in the catalytic enantioselective diethylzinc addition to benzaldehydes. __N__‐alkylated (1__R__,2__S__)‐norephedrine‐based derivative 3a gave the highest enantioselectivity. The effects of d