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Enantioselective addition of diethylzinc to aldehydes catalyzed by β-amino alcohols derived from (1R,2S)-norephedrine

✍ Scribed by Dilek Isik Tasgin; Canan Unaleroglu

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
123 KB
Volume
24
Category
Article
ISSN
0268-2605

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✦ Synopsis

Abstract

β‐Amino alcohols derived from (1__R__,2__S__)‐norephedrine were synthesized and used as ligands in the catalytic enantioselective diethylzinc addition to benzaldehydes. N‐alkylated (1__R__,2__S__)‐norephedrine‐based derivative 3a gave the highest enantioselectivity. The effects of different parameters on the enantioselectivity of the product were investigated. Copyright © 2009 John Wiley & Sons, Ltd.

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Enantioselective Addition of Diethylzinc to Aldehydes Catalyzed by Ethyl Nipecotate-Derived New Chiral Ligand. -In order to compare the chirality induction of chiral β-and γ-amino alcohols, chiral γ-amino alcohol DMM is synthesized and tested as catalyst in the addition of Et 2 Zn to various aldehyd