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Enantioselective addition of diethylzinc to aldehydes catalyzed by a β-amino alcohol derived from (+)-3-carene

✍ Scribed by Sudhir N Joshi; Sanjay V Malhotra

Book ID
104359874
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
121 KB
Volume
14
Category
Article
ISSN
0957-4166

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✦ Synopsis

A (+)-3-carene derived aminoalcohol was successfully used as a chiral ligand in the catalytic enantioselective diethylzinc addition to various aldehydes. Very high enantiomeric excess (up 98% in 1-(2-methoxyphenyl)-1-propanol) was obtained. A plausible mechanism has been suggested for the observed enantioselectivity.

📜 SIMILAR VOLUMES

Enantioselective addition of diethylzinc
Enantioselective addition of diethylzinc to aldehydes catalyzed by β-amino alcohols derived from (1R,2S)-norephedrine
✍ Dilek Isik Tasgin; Canan Unaleroglu 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 123 KB 👁 1 views

## Abstract β‐Amino alcohols derived from (1__R__,2__S__)‐norephedrine were synthesized and used as ligands in the catalytic enantioselective diethylzinc addition to benzaldehydes. __N__‐alkylated (1__R__,2__S__)‐norephedrine‐based derivative 3a gave the highest enantioselectivity. The effects of d