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Efficient Use of Ellman Safety-Catch Linker for Solid-Phase Assisted Synthesis of Multivalent Glycoconjugates

✍ Scribed by Díaz-Moscoso, Alejandro; Benito, Juan M.; Ortiz Mellet, Carmen; García Fernández, José M.


Book ID
127091569
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
187 KB
Volume
9
Category
Article
ISSN
1520-4766

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A new strategy for the solid-phase synthesis of unsymmetrical ureas is described. Upon treatment of Kenner safety-catch linker with an isocyanate, followed by TMSCHN 2 or iodoacetonitrile and an amine, the corresponding unsymmetrical ureas are released in solution.