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The Preparation of a New “Safety Catch” Ester Linker for Solid-Phase Synthesis

✍ Scribed by Beech, Claire L.; Coope, John F.; Fairley, Gary; Gilbert, Philip S.; Main, Brian G.; Plé, Karen

Book ID
111982132
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
86 KB
Volume
66
Category
Article
ISSN
0022-3263

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A new safety-catch protecting group and
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✍ Sathiah Thennarasu; Chuan-Fa Liu 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 434 KB

The use of two derivatives of 2-methoxy-4-methylsulfinylbenzyl alcohol is demonstrated as a safetycatch protecting group and linker for solid-phase peptide synthesis. The protecting group and linker are stable to TFA and are readily removed under reductive acidolytic conditions.