An oxidatively-activated safety catch linker for solid phase synthesis
β Scribed by Davies, Stephen G.; Mortimer, Duncan A. B.; Mulvaney, Andrew W.; Russell, Angela J.; Skarphedinsson, Hjalmar; Smith, Andrew D.; Vickers, Richard J.
- Book ID
- 121461808
- Publisher
- Royal Society of Chemistry
- Year
- 2008
- Tongue
- English
- Weight
- 446 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1477-0520
- DOI
- 10.1039/B802204F
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This review article focuses on concepts that incorporate safety-catch and multiply cleavable linkers in solid-phase synthesis. Discussed are specific applications of such linkers in the synthesis of peptides, peptide mimetics, and "small" organic molecules, as well as their limitations for particula
The use of two derivatives of 2-methoxy-4-methylsulfinylbenzyl alcohol is demonstrated as a safetycatch protecting group and linker for solid-phase peptide synthesis. The protecting group and linker are stable to TFA and are readily removed under reductive acidolytic conditions.