This review article focuses on concepts that incorporate safety-catch and multiply cleavable linkers in solid-phase synthesis. Discussed are specific applications of such linkers in the synthesis of peptides, peptide mimetics, and "small" organic molecules, as well as their limitations for particula
Thermally cleavable safety-catch linkers for solid phase chemistry
β Scribed by Helen E Russell; Richard W.A Luke; Mark Bradley
- Book ID
- 108379844
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 123 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The use of two derivatives of 2-methoxy-4-methylsulfinylbenzyl alcohol is demonstrated as a safetycatch protecting group and linker for solid-phase peptide synthesis. The protecting group and linker are stable to TFA and are readily removed under reductive acidolytic conditions.
We report here a new analytical construct based on a thiopyrimidine safety-catch linker. This construct adds to the existing portfolio of linkers available for facile monitoring of reactions conducted on solid support. A practical solution phase synthesis of the precursor is described, together with