Solid-phase synthesis of unsymmetrical u
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Daniela Fattori; Piero D'Andrea; Marina Porcelloni
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Article
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2003
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Elsevier Science
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French
β 150 KB
A new strategy for the solid-phase synthesis of unsymmetrical ureas is described. Upon treatment of Kenner safety-catch linker with an isocyanate, followed by TMSCHN 2 or iodoacetonitrile and an amine, the corresponding unsymmetrical ureas are released in solution.