Effect of the Tethering Groups of Chiral Stationary Phases Based on (+)‐(18‐Crown‐6)‐ 2,3,11,12‐Tetracarboxylic Acid on the Liquid Chromatographic Resolution of β‐Amino Acids
✍ Scribed by Hyun, Myung Ho; Cho, Yoon Jae; Kim, Jin Ah; Jin, Jong Sung
- Book ID
- 120580410
- Publisher
- Taylor and Francis Group
- Year
- 2003
- Tongue
- English
- Weight
- 198 KB
- Volume
- 26
- Category
- Article
- ISSN
- 1082-6076
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## Abstract A doubly tethered chiral stationary phase (CSP) containing N–CH~3~ amide linkage based on (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid was applied to the resolution of various β‐amino acids. The chiral recognition behaviors for the resolution of β‐amino acids on the doubly tethered C
## Abstract Flecainide, an antiarrythmic agent, and its analogs were resolved on a high performance liquid chromatographic chiral stationary phase (CSP) based on (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid with the use of a mobile phase consisting of methanol‐acetonitrile‐trifluoroacetic acid‐t