## Abstract Flecainide, an antiarrythmic agent, and its analogs were resolved on a high performance liquid chromatographic chiral stationary phase (CSP) based on (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid with the use of a mobile phase consisting of methanol‐acetonitrile‐trifluoroacetic acid‐t
Liquid chromatographic resolution of 1-aryl-1,2,3,4-tetrahydroisoquinolines on a chiral stationary phase based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid
✍ Scribed by Areum Lee; Hee Jung Choi; Kab Bong Jin; Myung Ho Hyun
- Book ID
- 108094466
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 291 KB
- Volume
- 1218
- Category
- Article
- ISSN
- 1873-3778
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## Abstract A doubly tethered chiral stationary phase (CSP) containing N–CH~3~ amide linkage based on (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid was applied to the resolution of various β‐amino acids. The chiral recognition behaviors for the resolution of β‐amino acids on the doubly tethered C
## Abstract A chiral stationary phase (CSP **1**) based on (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid was applied to the resolution of __N__‐(substituted benzoyl)‐α‐amino acid amides and esters. __N__‐(Substituted benzoyl)‐α‐amino acid amides were well resolved using a mixture of acetic acid‐t