Effect of glycosylation of a synthetic MUC1 mucin-core-related peptide on recognition by anti-mucin antibodies
β Scribed by Daniel I.R. Spencer; Michael R. Price; Saul J.B. Tendler; Cristina I. De Matteis; Tanja Stadie; Franz-Georg Hanisch
- Book ID
- 116123373
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 804 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0304-3835
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MUC1 mucin is a large complex glycoprotein expressed on normal epithelial cells in humans and overexpressed and under or aberrantly glycosylated on many malignant cancer cells which consequently allows recognition of the protein core by antibodies. In order to understand how glycosylation may modula
Human intestinal mucins are high molecular weight glycoproteins which protect and lubricate the epithelium of the gastrointestinal tract. In cases of malignant disease, mucins are abnormally expressed, overproduced or underglycosylated. This feature may enable the mucins to serve as tumour markers.