Effect of core epitope modification on the antibody recognition of a MUC2 mucin peptide
β Scribed by Katalin Uray; Ferenc Hudecz
- Book ID
- 113075697
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 448 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1381-1991
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Human intestinal mucins are high molecular weight glycoproteins which protect and lubricate the epithelium of the gastrointestinal tract. In cases of malignant disease, mucins are abnormally expressed, overproduced or underglycosylated. This feature may enable the mucins to serve as tumour markers.
## Abstract C595 is a murine lgG~3~ monoclonal antibody (MAb) raised against human urinary mucin. C595 antibody binds to the protein core of the MUCβ1 mucin (the polymorphic epithelial mucin, PEM) which is elevated in tissue and secretions from human breast carcinomas. The antibody defines the tetr