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Effect of D-Amino Acid Substitution in a Mucin 2 Epitope on Mucin-Specific Monoclonal Antibody Recognition

✍ Scribed by Katalin Uray; Judit Kajtár; Elemér Vass; Michael R. Price; Miklós Hollósi; Ferenc Hudecz

Book ID
115568207
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
117 KB
Volume
378
Category
Article
ISSN
0003-9861

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Human intestinal mucins are high molecular weight glycoproteins which protect and lubricate the epithelium of the gastrointestinal tract. In cases of malignant disease, mucins are abnormally expressed, overproduced or underglycosylated. This feature may enable the mucins to serve as tumour markers.