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Structural Effects of O-Glycosylation on a 15-Residue Peptide from the Mucin (MUC1) Core Protein †

✍ Scribed by Kirnarsky, Leo; Prakash, Om; Vogen, Shawn M.; Nomoto, Mitsuharu; Hollingsworth, Michael A.; Sherman, Simon

Book ID
126830057
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
90 KB
Volume
39
Category
Article
ISSN
0006-2960

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Human intestinal mucins are high molecular weight glycoproteins which protect and lubricate the epithelium of the gastrointestinal tract. In cases of malignant disease, mucins are abnormally expressed, overproduced or underglycosylated. This feature may enable the mucins to serve as tumour markers.