𝔖 Bobbio Scriptorium
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Effect of chronic lead exposure on biopterin metabolism in the rat neostriatum

✍ Scribed by Daniel Martínez-Fong; M. E. Gutiérrez; J. Aceves

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
301 KB
Volume
26
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

Chronic (3 months) lead exposure increased the quinonoid dihydropteridine reductase activity and the tetrahydrobiopterin content but did not affect the GTP‐cyclohydrolase activity and the dihydrobiopterin content. These results suggest that lead intoxication may enhance dopamine metabolism in neostriatum by increasing the content of tetrahydrobiopterin, the regulating cofactor of tyrosine hydroxylase activity.

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