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The effects of chronic ozone exposure on pulmonary collagen content and collagen synthesis in rats

✍ Scribed by C. Filipoicz; R. McCauley

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
367 KB
Volume
6
Category
Article
ISSN
0260-437X

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✦ Synopsis

Male rats were exposed to 0.125,0.25 or 0.5 ppm of ozone or clean air for up to 1 year. During this exposure period there was little evidence for collagen accumulation in the lungs. However, the rate of incorporation of tritriated proline into both lung collagen and total lung protein was accelerated. These data suggest that exposure to ozone under these conditions results in an increase in the turnover of collagen as well as other lung proteins.

period of 1 year, ten rats from each group were removed and transported to Wayne State University

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