𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The effect of in vivo exposure to diesel exhaust on rat hepatic and pulmonary microsomal activities

✍ Scribed by C. Navarro; J. Charboneau; R. McCauley

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
315 KB
Volume
1
Category
Article
ISSN
0260-437X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The effect of exposure to three concentrations of diesel exhaust on several heptic and pulmonary activities has been tested. After one year of exposure, the ability of liver microsomes to oxidize benzo[Ξ±]pyrene to more polar metabolites was not increased. Further studies with liver microsomes showed that, after several months of exposure, there was no evidence for the induction of either cytochrome P‐450, cytochrome P‐448 or NADPH dependent cytochrome c reductase. The ability of pulmonary microsomes to generate polar metabolites from benzo[Ξ±]pyrene was impaired after one year of exposure to the highest concentration of exhaust (1500 ΞΌg m^βˆ’3^). The process by which the exposure causes this inhibition is not clear.

πŸ“œ SIMILAR VOLUMES

Effect of exposure to diesel exhaust on
Effect of exposure to diesel exhaust on pulmonary prostaglandin dehydrogenase (PGDH) activity
✍ A. Chaudhari; R. G. Farrer; S. Dutta πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 English βš– 263 KB πŸ‘ 1 views

## Abstract There has been evidence that an acute exposure of laboratory animals to nitrogen dioxide (NO~2~) for a short period of time can cause marked inhibition of pulmonary PGDH activity. Since diesel exhaust contains NO~2~, this investigation was undertaken to determine the effect of long‐term

Reduction in adverse effect on pulmonary
Reduction in adverse effect on pulmonary function after exposure to filtered diesel exhaust
✍ Ulf Ulfvarson; Rolf Alexandersson πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 443 KB πŸ‘ 2 views

## Abstract A statistically significant temporary reduction on pulmonary function was measured with spirometry in stevedores on a roll‐on‐roll‐off ro‐ro ship who were exposed to diesel exhausts from trucks during a work shift. When all trucks were equipped with specially designed microfilters mount

Effects of in vivo administration of det
Effects of in vivo administration of detergents on the hepatic microsomal cytochrome P-450 system in rat
✍ Yoshiro Miura πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 463 KB πŸ‘ 1 views

The influence of in vivo administration of detergents on the hepatic microsomal cytochrome P-450 system was studied in rat. Male Wistar rats were administered detergents, Emulgen 913 (50 mg or 100 mg kg-' of body weight (B.W.)), or sodium dodecylsulfate (SDS, 25 mg or 50 mg kg-' of B.W.) intraperito

The effects of variation in dietary prot
The effects of variation in dietary protein and ethanol on hepatic microsomal drug metabolism in the rat
✍ Mack C. Mitchell; Esteban Mezey; Willis C. Maddrey πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 English βš– 484 KB πŸ‘ 1 views

The effects of chronic ethanol consumption and variations in dietary protein content on micro-soma1 drug metabolism were studied in rats pair-fed liquid diets containing 10, 20, or 30% dietary protein with or without ethanol. In uiuo drug metabolism was measured by aminopyrine breath tests and amino

The effects of chronic ozone exposure on
The effects of chronic ozone exposure on pulmonary collagen content and collagen synthesis in rats
✍ C. Filipoicz; R. McCauley πŸ“‚ Article πŸ“… 1986 πŸ› John Wiley and Sons 🌐 English βš– 367 KB πŸ‘ 1 views

Male rats were exposed to 0.125,0.25 or 0.5 ppm of ozone or clean air for up to 1 year. During this exposure period there was little evidence for collagen accumulation in the lungs. However, the rate of incorporation of tritriated proline into both lung collagen and total lung protein was accelerate