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Influence of chronic lead exposure on hormone levels in developing rats

✍ Scribed by Adolf Vyskočil; Zdeněk Fiala; Eva Ettlerová; Iva Tenjnorová

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
138 KB
Volume
10
Category
Article
ISSN
0260-437X

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✦ Synopsis

Abstract

The effect of five months' exposure to 0.5% lead acetate in drinking water on hormone levels of developing rats was studied. The hypothalamic and striatic concentrations of noradrenaline (NA) were decreased in both sexes. In female but not in male rats, blood and adrenal catecholamines and serum corticosterone concentrations were aiso increased. No changes were observed in serum thyroxine and 3,5,3′‐triiodothyronine levels. Our results indicate that female developing rats are more susceptible to lead than male rats. In female rats, both the hypothalamo‐pituitary‐adrenal and sympatho‐adrenal systems seem to be affected by this lead exposure; in male rats, only the latter system is affected.

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