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Effect of single gallium arsenide exposure on some biochemical variables in porphyrin metabolism in rats

✍ Scribed by S. J. S. Flora; S. Das Gupta

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 142 KB
Volume: 12
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550120508

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✦ Synopsis

Gallium arsenide (GaAs) inhibited, dose dependently, 6-aminolevulinic acid dehydratase (ALAD) activity in blood (as observed on days 1, 7 and 15), liver and brain (on day 15) after a single oral treatment. Levels of blood zinc protoporphyrin (ZPP) and urinary 6-aminolevulinic acid (ALA) excretion were elevated on day 7 and day 15 following exposure to 2000 mg kg-' GaAs. A dose-dependent increase in blood As contents was observed while blood Ga was detectable only at higher doses.

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