Effect of acute and chronic stress on amobarbital metabolism in the rat

✍ Scribed by James Edward Huff; Stanley M. Shaw; John E. Christian

• Publisher: John Wiley and Sons
• Year: 1970
• Tongue: English
• Weight: 380 KB
• Volume: 59
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600590131

✦ Synopsis

Labeled amobarbital was employed in an investigation of the utilization of urinary excretion of a labeled compound as an index for indicating altered amobarbital metabolism due to a stress. A study of the effect of an external acute unilateral hindleg ligation stress showed significant differences in amobarbital and/or metabolite urinary excretion patterns between stress and control groups. Adrenal ascorbic acid as an index of acute stress showed a significant difference between groups. Repeated injection of amobarbital as an internal chronic stress resulted in a significant difference between stress and control rat urinary excretion of amobarbital and/or metabolites.

Keyphrases

A m ~b a r b i t a l -~~C metabolism-acute, chronic stress