Dose-Dependent Pharmacokinetics of Carbamazepine in Rats: Determination of the Formation Clearance of Carbamazepine-10,11-epoxide
β Scribed by Rory P. Remmel; Michael W. Sinz; James C. Cloyd
- Book ID
- 110343128
- Publisher
- Springer US
- Year
- 1990
- Tongue
- English
- Weight
- 886 KB
- Volume
- 07
- Category
- Article
- ISSN
- 0724-8741
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A highly-sensitive microcolumn HPLC method for the simultaneous determination of carbamazepine and carbamazepine-l0,ll-epoxide in human serum and saliva is described. The method was successfully employed for the study of pharmacokinetics of carbamazepine in humans. After oral administration of 100 a
Carbamazepine-lO,l l-epoxide is a metabolite of carbamazepine that has been identified in the urine OT the rat and in the urine and plasma of marV and which, in the rat, has been shown to have antiepileptic properties comparable to those of the parent drug. It has therefore been suggested3 that, in