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In vivo solid-phase microextraction for single rodent pharmacokinetics studies of carbamazepine and carbamazepine-10,11-epoxide in mice

✍ Scribed by Dajana Vuckovic; Inés de Lannoy; Brad Gien; Yingbo Yang; Florin Marcel Musteata; Robert Shirey; Leonard Sidisky; Janusz Pawliszyn


Book ID
108094269
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
500 KB
Volume
1218
Category
Article
ISSN
1873-3778

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A highly-sensitive microcolumn HPLC method for the simultaneous determination of carbamazepine and carbamazepine-l0,ll-epoxide in human serum and saliva is described. The method was successfully employed for the study of pharmacokinetics of carbamazepine in humans. After oral administration of 100 a