Simultaneous determination by gas-liquid chromatography of carbamazepine and carbamazepine-10,11-epoxide in plasma

✍ Scribed by Robin E. Chambers

• Publisher: Elsevier Science
• Year: 1978
• Tongue: English
• Weight: 196 KB
• Volume: 154
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(00)98476-0

✦ Synopsis

Carbamazepine-lO,l l-epoxide is a metabolite of carbamazepine that has been identified in the urine OT the rat and in the urine and plasma of marV and which, in the rat, has been shown to have antiepileptic properties comparable to those of the parent drug. It has therefore been suggested3 that, in human plasma, the epoxide should be measured in addition to carbamazepine in order to correlate better the drug level with therapeutic effect. The simple gas-liquid chromatographic (GLC) procedure described recently by Chambers and Cooke4 for monitoring levels of carbamazepine may readily be adapted for the simultaneous determination of carbamazepine and carbamazepine-10,llepoxide in plasma. In this paper, the modi-fied~procedure is described.