Simultaneous determination of carbamazepine, oxcarbazepine and their main metabolites in plasma by liquid chromatography
β Scribed by G.P. Menge; J.P. Dubois; G. Bauer
- Publisher
- Elsevier Science
- Year
- 1987
- Weight
- 481 KB
- Volume
- 414
- Category
- Article
- ISSN
- 0378-4347
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Carbamazepine-lO,l l-epoxide is a metabolite of carbamazepine that has been identified in the urine OT the rat and in the urine and plasma of marV and which, in the rat, has been shown to have antiepileptic properties comparable to those of the parent drug. It has therefore been suggested3 that, in
## Abstract A highβperformance liquid chromatography assay with ultraviolet detection was developed for the simultaneous determination of the antiβepileptic drugs lamotrigine, carbamazepine and zonisamide in human plasma and serum. Lamotrigine, carbamazepine, zonisamide and the internal standard ch