Single dose pharmacokinetics of carbamazepine-10,11-epoxide in patients on lamotrigine monotherapy
β Scribed by F. Pisania; B. Xiao; A. Fazio; E. Spina; E. Perucca; T. Tomson
- Book ID
- 108022876
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 410 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0920-1211
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π SIMILAR VOLUMES
A highly-sensitive microcolumn HPLC method for the simultaneous determination of carbamazepine and carbamazepine-l0,ll-epoxide in human serum and saliva is described. The method was successfully employed for the study of pharmacokinetics of carbamazepine in humans. After oral administration of 100 a
The in vivo serum protein binding characteristics of carbamazepine (CBZ) and carbamazepine-10,11-epoxide (CBZ-E) were assessed in sera from 23 paediatric patients on CBZ monotherapy. We assumed that CBZ and CBZ-E binding to serum proteins comprised specific binding sites on alpha 1-acid glycoprotein